Now that you have identified risks and identified manners in which to eliminate or reduce risk, you must now implement these processes. This could be changes in route of exposure, duration of exposure, materials, processes, geometries of the surface, and formulations of materials. A suggestion of putting warning labels rather than testing to quantify risk.
Animal testing should be the last resort after chemical, physical and in vitro evaluations have been exhausted.
After all of the previous steps, what risks still remain.
Post Production monitoring
Monitoring of adverse events once on the market and updating the file with newly acquired information.